Belote J M, Baker B S
Proc Natl Acad Sci U S A. 1982 Mar;79(5):1568-72. doi: 10.1073/pnas.79.5.1568.
The transformer-2 (tra-2) locus is one of a set of regulatory loci that control sex determination in Drosophila melanogaster. Temperature-shift experiments with temperature-sensitive tra-2 mutants demonstrate that within single cell lineages tra-2+ function is required at several times, and probably continuously, during development for the occurrence of a series of determinative decisions necessary for female sexual differentiation. Analysis of the effects of tra-2 in the genital disc demonstrates that the tra-2+ function is necessary in females both to prevent male sexual differentiation and to permit female differentiation. These and other results support the model that the tra-2+ and tra+ loci act to control the expression of the bifunctional doublesex (dsx) locus.
transformer-2（tra-2）基因座是控制黑腹果蝇性别决定的一组调控基因座之一。对温度敏感的tra-2突变体进行的温度转换实验表明，在单个细胞谱系中，tra-2+功能在发育过程中需要多次发挥作用，并且可能是持续发挥作用，以实现雌性性别分化所需的一系列决定性事件。对tra-2在生殖盘的作用分析表明，tra-2+功能对于雌性防止雄性性别分化和实现雌性分化都是必需的。这些结果以及其他结果支持了这样一个模型，即tra-2+和tra+基因座共同作用来控制双功能的双性基因（dsx）座的表达。
