在向人体输注前列环素终止后血小板活性增加。

Increased platelet activity after termination of prostacyclin infusion into man.

作者信息

Dembinska-Kiec A, Zmuda A, Grodzinska L, Bieron K, Basista M, Kedzior A, Kostka-Trabka E, Telesz E, Zelazny T

出版信息

Prostaglandins. 1981 May;21(5):827-32. doi: 10.1016/0090-6980(81)90239-2.

Abstract

Infusion of PGI2 at a dose of 5 or 10 ng/kg/min during 72 hours into patients with peripheral vascular disease was followed by increased susceptibility of platelets to proaggregatory action of ADP and collagen but not that of arachidonate. The above effects were observed 24 hours after termination of infusion of PGI2. A tendency to an increased formation of TXA2 in PRP aggregated by arachidonate was also noticed. Infusion of PGI2 at a dose of 2 mg/kg/min during 72 hours into the patients caused the decreased platelet aggregability to ADP and arachidonate but not to collagen, and a decreased tendency to production of TXA2 in PRP aggregated by arachidonate. The existence of a "rebound effect" in platelets after a long term PGI2 therapy is suggested.

摘要

对周围血管疾病患者以5或10 ng/kg/分钟的剂量输注前列环素（PGI2）72小时后，血小板对二磷酸腺苷（ADP）和胶原蛋白的促聚集作用的敏感性增加，但对花生四烯酸的敏感性未增加。上述效应在PGI2输注终止后24小时观察到。还注意到在由花生四烯酸聚集的富血小板血浆（PRP）中血栓素A2（TXA2）形成增加的趋势。对患者以2 mg/kg/分钟的剂量输注PGI2 72小时导致血小板对ADP和花生四烯酸的聚集性降低，但对胶原蛋白的聚集性未降低，并且在由花生四烯酸聚集的PRP中TXA2产生的趋势降低。提示长期PGI2治疗后血小板存在“反弹效应”。