阿片肽对促性腺激素分泌的影响。

Effect of opioid peptides on gonadotrophin secretion.

作者信息

Motta M, Martini L

出版信息

Acta Endocrinol (Copenh). 1982 Mar;99(3):321-5. doi: 10.1530/acta.0.0990321.

DOI:10.1530/acta.0.0990321

Abstract

The intraventricular injection of 25 micrograms of Methionine-Enkephalin (Met-Enk) induces a significant increase of serum LH levels in long-term ovariectomized rats 15, 30 and 60 min following administration. The synthetic Met-Enk agonistic analogue [D-Ala2] methionine-Enkephalinamide ([D-Ala2]Met-Enk) also enhances significantly serum LH levels at 30 and 60 min; under the same experimental conditions neither Met-Enk nor [D-Ala2]Met-Enk modifies serum levels of FSH following intraventricular injections into ovariectomized animals. It is concluded that, under particular circumstances, opioid peptides of the Met-Enk family may stimulate LH release.

摘要

向长期卵巢切除大鼠脑室内注射25微克甲硫氨酸脑啡肽（Met-Enk）后15、30和60分钟，血清促黄体生成素（LH）水平显著升高。合成的Met-Enk激动类似物[D-Ala2]甲硫氨酸脑啡肽酰胺（[D-Ala2]Met-Enk）在30和60分钟时也能显著提高血清LH水平；在相同实验条件下，向卵巢切除动物脑室内注射Met-Enk或[D-Ala2]Met-Enk均不会改变血清促卵泡生成素（FSH）水平。得出的结论是，在特定情况下，Met-Enk家族的阿片肽可能刺激LH释放。