Bryan R N, Johnston D
AJNR Am J Neuroradiol. 1982 Mar-Apr;3(2):117-20.
Electrical activity in cells directly exposed to water-soluble radiographic contrast agents was investigated by intracellular recordings from neurons of the abdominal ganglia of Aplysia. Measurements of membrane resting potential, membrane conductance, synaptic and action potential configuration, and spontaneous electrical activity were performed. Test solutions included sodium diatrizoate, meglumine iothalamate, metrizamide, and control solutions. Solutions (100 and 200 mOsm) of these agents did not significantly alter resting membrane potential, membrane conductance, action potential frequency or configuration, or excitatory postsynaptic potentials. Inhibitory postsynaptic potentials were suppressed by contrast agents. These results suggest that contrast agents affect at least some neurons by disinhibition.
通过对海兔腹神经节神经元进行细胞内记录，研究了直接暴露于水溶性放射造影剂的细胞中的电活动。进行了膜静息电位、膜电导、突触和动作电位形态以及自发电活动的测量。测试溶液包括泛影酸钠、碘他拉葡胺、甲泛葡胺和对照溶液。这些药剂的溶液（100和200毫渗量）并未显著改变静息膜电位、膜电导、动作电位频率或形态，或兴奋性突触后电位。造影剂可抑制抑制性突触后电位。这些结果表明，造影剂至少通过去抑制作用影响一些神经元。
