Chantepie A, Gold F, Maurage C, Despert F, Laugier J
Arch Fr Pediatr. 1982 Feb;39(2):85-9.
Gastro-intestinal (G-I) disorders were studied in 95 premature neonates. Each child presented with at least one of the features usually associated with mesenteric ischemia. Nearly all the children had been fed early with tyndallized maternal milk. No certain necrotizing enterocolitis (NEC) was observed; however, it was suspected in 4 children (4.2%) and in 7 (7.3%), minor changed occurred. Among the 13 factors examined which might be responsible for inducing NEC, only 2 were correlated with G-I disorders: low birth weight (less than 1,500 gm) and occurrence of secondary apnea or asphyxia incidents during mechanical ventilation. This study led to the following practical conclusion: maintenance of early enteral feeding in prematures theoretically at risk for G-I disorders, taking into account the low incidence of severe G-I impairments and of the advantages of such a feeding method, while carefully supervising intestinal symptoms; preventative and temporary interruption of feeding in low weight prematures, in case of acute asphyxia or hypoxia episodes.
对95名早产儿的胃肠道疾病进行了研究。每个孩子都至少表现出一种通常与肠系膜缺血相关的特征。几乎所有孩子都早期喂了经过巴氏消毒的母乳。未观察到确诊的坏死性小肠结肠炎(NEC);然而,有4名儿童(4.2%)疑似患有该病,7名儿童(7.3%)出现了轻微变化。在检查的可能导致NEC的13个因素中,只有2个与胃肠道疾病相关:低出生体重(低于1500克)以及机械通气期间继发性呼吸暂停或窒息事件的发生。这项研究得出了以下实际结论:考虑到严重胃肠道损伤的低发生率以及这种喂养方法的优点,在理论上有胃肠道疾病风险的早产儿中维持早期肠内喂养,同时仔细监测肠道症状;对于低体重早产儿,在发生急性窒息或缺氧发作时,预防性地暂时中断喂养。