Jarrige J F, Boucher D, Grizard G, André M
J Physiol (Paris). 1981 Mar;77(8):877-82.
Pinealectomy was performed on rat foetuses aged 16.5 days +/- 8 h. Sham-pinealectomized animals were bred under the same conditions. Animals were killed when 50 or 64-days old. Plasma LH response to Gn-RH (100 ng via carotid artery) was studied in undisturbed adult male rats. 1. Body weight at birth was higher in pinealectomized rats than in sham-pinealectomized animals but, in 50 or 64-day-old body weights were not different. 2. In 50-day-old pinealectomized rats, absolute weights of testis and epididymis were higher than in sham-pinealectomized animals. When organ weights were compared to body weight by analysis of covariance, only the epididymis weight was enhanced by pinealectomy. 3. In 64-day-old animals, foetal pinealectomy did not increase reproductive organ weights. In contrast, prostate weight was decreased after pineal removal. 4. Plasma and pituitary gonadotropins were not modified by foetal pinealectomy. In undisturbed adult male rats, the plasma LH response to Gn-RH administration was identical in pinealectomized rats and in sham-pinealectomized animals. These findings may suggest an inhibitory effect of the pineal and foetal growth, but foetal pinealectomy exerts no gonadal stimulation in the adult male rats.
对16.5日龄±8小时的大鼠胎儿进行松果体切除术。假松果体切除的动物在相同条件下饲养。动物在50或64日龄时处死。在未受干扰的成年雄性大鼠中研究了血浆促黄体生成素（LH）对促性腺激素释放激素（Gn-RH，经颈动脉注射100纳克）的反应。1. 松果体切除的大鼠出生时体重高于假松果体切除的动物，但在50或64日龄时体重无差异。2. 在50日龄的松果体切除大鼠中，睾丸和附睾的绝对重量高于假松果体切除的动物。通过协方差分析将器官重量与体重进行比较时，只有附睾重量因松果体切除术而增加。3. 在64日龄的动物中，胎儿期松果体切除并未增加生殖器官重量。相反，松果体切除后前列腺重量降低。4. 胎儿期松果体切除未改变血浆和垂体促性腺激素。在未受干扰的成年雄性大鼠中，松果体切除大鼠和假松果体切除动物对Gn-RH给药的血浆LH反应相同。这些发现可能提示松果体对胎儿生长有抑制作用，但胎儿期松果体切除对成年雄性大鼠无性腺刺激作用。
