胆囊收缩素八肽对大鼠体温的影响。

Effect of cholecystokinin octapeptide on body temperature in the rat.

作者信息

Katsuura G, Itoh S

出版信息

Jpn J Physiol. 1981;31(6):849-58. doi: 10.2170/jjphysiol.31.849.

DOI:10.2170/jjphysiol.31.849

Abstract

The C-terminal octapeptide of cholecystokinin (CCK-8) injected into the lateral ventricle of rats produced a lowering of body temperature. CCK-8 potentiated pentobarbital-induced hypothermia, but not the ethanol one. Thyrotropin releasing hormone (TRH) and prostaglandin E2 (PGE2) antagonized the hypothermic effect of CCK-8. Non-sulfated CCK-8 was ineffective in lowering body temperature, indicating that sulfated tyrosine in the CCK molecule is indispensable for its hypothermic action. Caerulein was found to possess rather less activity compared with CCK-8.

摘要

将胆囊收缩素的C末端八肽（CCK - 8）注入大鼠侧脑室会导致体温降低。CCK - 8增强了戊巴比妥诱导的体温过低，但对乙醇诱导的体温过低没有增强作用。促甲状腺激素释放激素（TRH）和前列腺素E2（PGE2）拮抗CCK - 8的体温过低作用。非硫酸化的CCK - 8在降低体温方面无效，这表明CCK分子中的硫酸化酪氨酸对于其体温过低作用是不可或缺的。发现蛙皮素与CCK - 8相比活性较低。