Seon B K
Mol Immunol. 1982 Jan;19(1):83-6. doi: 10.1016/0161-5890(82)90249-8.
The amino-terminal amino acid sequences of Bence Jones (BJ) proteins isolated from the urine specimens of two patients (JBL and PSM) with adult Fanconi syndrome were determined. Both BJ proteins JBL and PSM are of the VkI subclass. However, protein JBL contains tyrosine at position 14 whereas protein PSM contains glutamine at position 40. Neither tyrosine 14 nor glutamine 40 has previously been reported for immunoglobulin (Ig) L-chains of any species including humans, the mouse, rabbit, rat, guinea pig. pig, dog, chicken, turkey, and shark. In addition, protein JBL contains alanine 22 whereas protein PSM contains arginine 30. Both alanine 22 and arginine 30 have been only rarely found in Ig L-chains.
测定了从两名患有成人范可尼综合征的患者（JBL和PSM）尿液标本中分离出的本-周（BJ）蛋白的氨基末端氨基酸序列。BJ蛋白JBL和PSM均属于VkI亚类。然而，蛋白JBL在第14位含有酪氨酸，而蛋白PSM在第40位含有谷氨酰胺。包括人类、小鼠、兔子、大鼠、豚鼠、猪、狗、鸡、火鸡和鲨鱼在内的任何物种的免疫球蛋白（Ig）轻链，此前均未报道过第14位的酪氨酸或第40位的谷氨酰胺。此外，蛋白JBL含有第22位的丙氨酸，而蛋白PSM含有第30位的精氨酸。第22位的丙氨酸和第30位的精氨酸在Ig轻链中均很少见。
