Seeger W, Wolf H, Stähler G, Neuhof H, Róka L
Prostaglandins. 1982 Feb;23(2):175-84. doi: 10.1016/0090-6980(82)90044-2.
In the model of isolated, ventilated rabbit lungs, perfused with isoionic and isooncotic fluid, the addition of arachidonic acid to the perfusion fluid or the liberation of arachidonic acid by the Ca-ionophore A 23187 result in an increase in pulmonary vascular resistance and permeability. The former can be ascribed to cyclooxygenase products, the latter to lipoxygenase products of arachidonic acid. The effect of alpha-tocopherol, its chromane compound, alpha-tocopherolquinone, phytol, 2-methyl-1,4-naphthoquinone, 2-methyl-3-phytyl-1,4-naphthoquinone and of superoxide dismutase (SOD) on the increase in pulmonary vascular resistance and permeability was investigated. A membrane effect of the phytyl side chain and an antioxidative effect of the chromane compound can be distinguished: phytol increase the arachidonate-induced rise of pulmonary vascular resistance and permeability, whereas the chromane compound decreases both to a large degree. Methyl-phytyl-naphthoquinone and methyl-naphthoquinone gave equivalent results. SOD decreases the enhanced vascular resistance and the vascular leakage. The possibility of antioxidative therapy in acute pulmonary lesions with vascular leakage and increased vascular resistance is discussed.
在灌注等离子和等渗液体的离体通气兔肺模型中，向灌注液中添加花生四烯酸或通过钙离子载体A 23187释放花生四烯酸会导致肺血管阻力和通透性增加。前者可归因于环氧化酶产物，后者归因于花生四烯酸的脂氧化酶产物。研究了α-生育酚、其色满化合物、α-生育醌、叶绿醇、2-甲基-1,4-萘醌、2-甲基-3-植基-1,4-萘醌和超氧化物歧化酶（SOD）对肺血管阻力和通透性增加的影响。可以区分植基侧链的膜效应和色满化合物的抗氧化效应：叶绿醇增加花生四烯酸诱导的肺血管阻力和通透性升高，而色满化合物在很大程度上降低两者。甲基-植基-萘醌和甲基-萘醌给出了等效结果。SOD降低增强的血管阻力和血管渗漏。讨论了在伴有血管渗漏和血管阻力增加的急性肺部病变中进行抗氧化治疗的可能性。
