Hoffmann P, Schockenhoff B
Anaesthesist. 1982 Feb;31(2):68-72.
Etomidate in a new more concentrated solution given in 50 ml NaCl 0.9% was administrated to two groups of patients for prolonged sleep over 48-60 hours. The first group of patients got withdrawal symptoms after several operations. The second group contain seven patients after multiple injury, who were given the continuous infusion for adaptation to the respirator. The following levels were recorded:Psyst/diast, Part, HR; paO2, paCO2. After the administration of etomidate heart rate and blood pressure became normal. We did not find any significant changes, neither in the first group under spontaneous breathing of room air nor in the second under controlled respiration with room air. Blood pressure, heart rate, paO2 and paCO2 remained normal during the long term medication of etomidate.
将依托咪酯以新的更高浓度溶液溶于50毫升0.9%氯化钠溶液中，给予两组患者以延长48至60小时的睡眠时间。第一组患者在多次手术后出现戒断症状。第二组有7名多处受伤患者，给予持续输注以适应呼吸机。记录了以下指标：收缩压/舒张压、部分压力、心率；动脉血氧分压、动脉血二氧化碳分压。给予依托咪酯后心率和血压恢复正常。我们未发现任何显著变化，无论是在第一组患者在室内空气自发呼吸状态下，还是在第二组患者在室内空气控制呼吸状态下。在长期使用依托咪酯药物期间，血压、心率、动脉血氧分压和动脉血二氧化碳分压均保持正常。
