硝酸甘油对前列腺素和血栓素A2合成以及血小板聚集影响的研究。
Studies of the influence of nitroglycerin on the synthesis of prostaglandins and thromboxane A2 and on platelet aggregation.
作者信息
Rettkowski W, Pönicke K, Block H U, Giessler C, Dunemann A, Zehl U, Förster W
出版信息
Arzneimittelforschung. 1982;32(3):194-200.
PMID:6805480
Abstract
Nitroglycerin (NG) did not influence the synthesis of prostaglandins and thromboxanes in organs and microsomal fractions of various animal species (rat, pig, rabbit). NG is an inhibitor of platelet aggregation in vitro dependent on NG dose and platelet activator. NG is able to disaggregate ADP-induced platelet aggregation. An increased antiaggregatory effect was observed when a low concentration of PGI2 was combined with NG.
摘要
硝酸甘油（NG）对各种动物物种（大鼠、猪、兔）的器官和微粒体部分中前列腺素和血栓烷的合成没有影响。在体外，NG是一种血小板聚集抑制剂，其作用取决于NG剂量和血小板激活剂。NG能够使ADP诱导的血小板聚集解聚。当低浓度的前列环素（PGI2）与NG联合使用时，观察到抗聚集作用增强。
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