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硝酸甘油对前列腺素和血栓素A2合成以及血小板聚集影响的研究。

Studies of the influence of nitroglycerin on the synthesis of prostaglandins and thromboxane A2 and on platelet aggregation.

作者信息

Rettkowski W, Pönicke K, Block H U, Giessler C, Dunemann A, Zehl U, Förster W

出版信息

Arzneimittelforschung. 1982;32(3):194-200.

PMID:6805480
Abstract

Nitroglycerin (NG) did not influence the synthesis of prostaglandins and thromboxanes in organs and microsomal fractions of various animal species (rat, pig, rabbit). NG is an inhibitor of platelet aggregation in vitro dependent on NG dose and platelet activator. NG is able to disaggregate ADP-induced platelet aggregation. An increased antiaggregatory effect was observed when a low concentration of PGI2 was combined with NG.

摘要

硝酸甘油(NG)对各种动物物种(大鼠、猪、兔)的器官和微粒体部分中前列腺素和血栓烷的合成没有影响。在体外,NG是一种血小板聚集抑制剂,其作用取决于NG剂量和血小板激活剂。NG能够使ADP诱导的血小板聚集解聚。当低浓度的前列环素(PGI2)与NG联合使用时,观察到抗聚集作用增强。

相似文献

1
Studies of the influence of nitroglycerin on the synthesis of prostaglandins and thromboxane A2 and on platelet aggregation.硝酸甘油对前列腺素和血栓素A2合成以及血小板聚集影响的研究。
Arzneimittelforschung. 1982;32(3):194-200.
2
[The modification of the biosynthesis and effect of thromboxane A2 and prostacyclin by trapidil (Rocornal)].曲匹地尔(心可定)对血栓素A2和前列环素生物合成及作用的影响
Biomed Biochim Acta. 1983;42(2-3):283-99.
3
[Suppression of platelet aggregation as a result of two-component inhibition of a polyenzyme system of thromboxane synthesis].[由于对血栓素合成多酶系统的双组分抑制导致血小板聚集的抑制]
Dokl Akad Nauk SSSR. 1985 May-Jun;282(1):194-6.
4
Effects of nitroglycerin on human vascular prostacyclin and thromboxane A2 generation.硝酸甘油对人体血管前列环素和血栓素A2生成的影响。
J Lab Clin Med. 1983 Jul;102(1):116-25.
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Influence on thromboxane and malondialdehyde synthesis in human thrombocytes by various inhibitors of platelet function.血小板功能的各种抑制剂对人血小板中血栓素和丙二醛合成的影响。
Agents Actions Suppl. 1979(4):127-37.
6
Increased prostacyclin and thromboxane production in man during cardiopulmonary bypass.体外循环期间人体中前列环素和血栓素生成增加。
J Thorac Cardiovasc Surg. 1981 Aug;82(2):245-7.
7
Fish oil administration lowers prostacyclin production and the antiaggregatory activity of aortic walls more effectively than platelet aggregation and thromboxane in the rat.在大鼠中,给予鱼油对前列环素生成和主动脉壁抗聚集活性的降低作用,比对血小板聚集和血栓素的降低作用更有效。
Adv Prostaglandin Thromboxane Leukot Res. 1983;12:185-91.
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[Biosynthesis of prostaglandins and thromboxane in the blood platelets].[血小板中前列腺素和血栓素的生物合成]
Nihon Rinsho. 1978 Dec 10;36(12):3805-12.
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Effect of an inhibitor of TXA2 synthesis and of PGE2 on the formation of 12-L-hydroxy-5,8,10-heptadecatrienoic acid in human platelets.血栓素A2合成抑制剂和前列腺素E2对人血小板中12-L-羟基-5,8,10-十七碳三烯酸形成的影响。
Adv Prostaglandin Thromboxane Res. 1980;6:463-6.
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The stimulatory effect of prostacyclin (PGI2) on isolated rabbit and rat aorta is probably associated to the generation of a thromboxane A2 (TXA2) "like-material".前列环素(PGI2)对离体兔和大鼠主动脉的刺激作用可能与血栓素A2(TXA2)“样物质”的产生有关。
Arch Int Pharmacodyn Ther. 1983 Jan;261(1):79-89.

引用本文的文献

1
Mechanisms of the nitroglycerine-induced vasodilation in vascular smooth muscles of the rabbit and pig.硝酸甘油诱导兔和猪血管平滑肌血管舒张的机制。
J Physiol. 1983 Oct;343:233-52. doi: 10.1113/jphysiol.1983.sp014890.