Fekl W, Löhlein D
Infusionsther Klin Ernahr. 1982 Apr;9(2):56-63.
By means of the present clinical findings it is demonstrated that an improvement of the preoperative nutritional status goes along with a reduction of the postoperative rates of mortality and complications. The effects of postoperative catabolism compared with chronic protein losses are shown. It is demonstrated that acute catabolism is essentially at the cost of viscerally synthesized and functionally important protein systems whereas chronic states of catabolism mainly affect the structural protein of the overall organism. This differentiation appears to be of importance in selecting the perioperative nutritional treatment. It must be distinguished between a specific protein replacement therapy in cases of acute protein losses and a calorically adequate parenteral nutrition in chronic deficiency states and calorie deficits. On the basis of our own findings these conceptions are illustrated, and practical hints for performing the infusion therapy are given.
通过目前的临床研究结果表明,术前营养状况的改善与术后死亡率和并发症发生率的降低相关。展示了术后分解代谢与慢性蛋白质流失相比的影响。结果表明,急性分解代谢主要以内脏合成且功能重要的蛋白质系统为代价,而慢性分解代谢状态主要影响整个机体的结构蛋白。这种差异在选择围手术期营养治疗时似乎很重要。必须区分急性蛋白质流失情况下的特定蛋白质替代疗法以及慢性缺乏状态和热量不足时热量充足的肠外营养。基于我们自己的研究结果阐述了这些概念,并给出了进行输液治疗的实用建议。