Christensen M, Carlsen J, Josefsson L
Hoppe Seylers Z Physiol Chem. 1978 Jul;359(7):813-8. doi: 10.1515/bchm2.1978.359.2.813.
The significance of the terminal residues of the red pigment-concentrating hormone (RPCH: Glu-Leu-Asn-Phe-Ser-Pro-Gly-Trp-NH2) for its blanching effect on crustacean chromatophores has been investigated. The chemical synthesis of the following small analogues, starting from the C-terminal amino acid are described: Ac-Trp-NH2, Boc-Gly-Trp-NH2, Ac-Gly-Trp-NH2, Gly-Trp-NH2, Ac-Pro-Gly-Trp-NH2, Glu-Trp-NH2, Glu-Pro-Gly-Trp-NH2, Ac-Pro-Gly and Glu-Pro-Gly-NH2. Assay of the biological activity of the various synthetic compounds in the shrimp Leander adspersus has established that only the C-terminal tryptophan residue is indispensable for the blanching effect of the hormone, although elongation of the chain length improves its potency.
对红色素浓缩激素（RPCH：Glu-Leu-Asn-Phe-Ser-Pro-Gly-Trp-NH2）末端残基对甲壳类动物色素细胞的褪色作用的重要性进行了研究。描述了以下从小C端氨基酸开始的小类似物的化学合成：Ac-Trp-NH2、Boc-Gly-Trp-NH2、Ac-Gly-Trp-NH2、Gly-Trp-NH2、Ac-Pro-Gly-Trp-NH2、Glu-Trp-NH2、Glu-Pro-Gly-Trp-NH2、Ac-Pro-Gly和Glu-Pro-Gly-NH2。对各种合成化合物在虾Leander adspersus中的生物活性测定表明，尽管链长的延长提高了其效力，但只有C端色氨酸残基对于激素的褪色作用是必不可少的。
