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食蟹猴(猕猴)慢性一氧化碳暴露的血流动力学和代谢效应

Hemodynamic and metabolic effects of chronic carbon monoxide exposure in cynomolgus monkeys (Macaca fascicularis).

作者信息

Dhindsa D S, Ochsner A J

出版信息

J Med Primatol. 1981;10(4-5):255-62. doi: 10.1159/000460082.

DOI:10.1159/000460082
PMID:6806477
Abstract

Cardio-respiratory data were obtained on four adult female cynomolgus monkeys, intermittently exposed to CO for eight months and compared with data obtained from the same animals after five weeks of recovery. Due to CO exposure, the arteriovenous oxygen concentration difference and oxygen consumption decreased and blood oxygen affinity increased. However, there was no significant change in cardiac output and mixed venous PO2. The cynomolgus monkeys adapted to chronic CO exposure by reducing their metabolic rate.

摘要

对四只成年雌性食蟹猴获取了心肺数据,这些猴子间歇性暴露于一氧化碳中达八个月,并与恢复五周后从同一动物身上获取的数据进行比较。由于暴露于一氧化碳,动静脉氧浓度差和氧耗量降低,而血液氧亲和力增加。然而,心输出量和混合静脉血氧分压没有显著变化。食蟹猴通过降低其代谢率来适应慢性一氧化碳暴露。

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引用本文的文献

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J Am Assoc Lab Anim Sci. 2008 Jan;47(1):22-5.
2
Hemodynamic response to carbon monoxide.对一氧化碳的血流动力学反应。
Environ Health Perspect. 1988 Apr;77:121-30. doi: 10.1289/ehp.8877121.
3
Is there a connection between carbon monoxide exposure and hypertension?一氧化碳暴露与高血压之间存在关联吗?
Environ Health Perspect. 1991 Nov;95:191-8. doi: 10.1289/ehp.9195191.