Geiseler D, Wahl R, Kallee E
Methods Find Exp Clin Pharmacol. 1982;4(1):73-8.
A simple mathematical model for the thyroid hormone stimulation in plasma after intravenous administration of pharmacological doses of thyroid hormone binding carrier proteins is described. The model concept is based on the observation of the time course of both radioactive labelled and unlabelled thyroid hormones before and after protein loading in rabbits. All model parameters are derived from experimental measurements in order to guarantee the identifiability with physiological data. The presented initial study could be a theoretical basis for a more effective therapy of thyroid storm by dialysis or plasma exchange methods.
描述了一种静脉注射药理剂量甲状腺激素结合载体蛋白后血浆中甲状腺激素刺激的简单数学模型。该模型概念基于对兔子蛋白质负荷前后放射性标记和未标记甲状腺激素时间进程的观察。所有模型参数均来自实验测量，以确保与生理数据的可识别性。所呈现的初步研究可为通过透析或血浆置换方法更有效治疗甲状腺风暴提供理论基础。
