Pediatric transfusion: considerations by age and blood component.

Transfusion in the pediatric age group requires careful consideration of the patient's weight and age because of potential problems with intravascular volume and difficulty with administration of the blood product. Different age groups have varied disease processes that require specific blood components. A correct diagnosis is essential for their proper choice and use. Common blood components used include red blood cells, platelets, granulocytes, factor VIII preparations, and prothrombin complex concentrates. Bone marrow transplantation and apheresis are new therapeutic modalities available through immunohematology-hemotherapy units. Adverse reactions to blood components include immediate and delayed types. The choice of a blood component should be related to clinical need, with overall concern for benefit-to-risk potential for the pediatric patient.