Gross J B, Smith L, Smith T C
Anesthesiology. 1982 Jul;57(1):18-21. doi: 10.1097/00000542-198207000-00005.
Dual isohypercapnic studies on the time course of depression following intravenous diazepam permit detailed analysis of changes in the ventilatory response to carbon dioxide. The mean slope of the CO2 response curves of eight healthy volunteers dropped from 2.38 to 1.21 1 . min-1 . mmHg-1 ( P less than 0.05) within three minutes after injection of diazepam 0.4 mg/kg. Twenty-five minutes after injection, the slope was only 1.49 1 . min-1 . mmHg-1, still significantly lower than control (P less than 0.05). At 30 min, the slope has increased to 1.73 1 . min-1 . mmHg-1 and was no longer different from control at the 0.05 level of significance. There was also a significant correlation between the slope of the CO2 response curve and level of consciousness (r = 0. 81). There was little or no displacement of the response curve at any selected ventilation except as accounted for by the slope change. The authors conclude that ventilatory depression resulting from intravenous diazepam begins within one minute and lasts at least 25 min after injection.
关于静脉注射地西泮后抑郁时间进程的双重等碳酸血症研究，能够详细分析对二氧化碳通气反应的变化。8名健康志愿者的二氧化碳反应曲线的平均斜率在注射0.4mg/kg地西泮后3分钟内从2.38降至1.21L·min⁻¹·mmHg⁻¹（P<0.05）。注射后25分钟，斜率仅为1.49L·min⁻¹·mmHg⁻¹，仍显著低于对照组（P<0.05）。在30分钟时，斜率增加到1.73L·min⁻¹·mmHg⁻¹，在0.05的显著性水平下与对照组不再有差异。二氧化碳反应曲线的斜率与意识水平之间也存在显著相关性（r = 0.81）。除了由斜率变化所解释的情况外，在任何选定的通气条件下，反应曲线几乎没有或没有位移。作者得出结论，静脉注射地西泮引起的通气抑制在注射后1分钟内开始，至少持续25分钟。
