Carrera G, Fernandez Y, Mitjavila S, Derache R
Arch Environ Contam Toxicol. 1982;11(2):239-44. doi: 10.1007/BF01054902.
The effects of PCBs, administered intragastrically, were studied on partially hepatectomized (70%) rats. Seven days after hepatectomy, a relationship was noted between the increase in the degree of chlorination of the biphenyl molecule and the hypertrophy and lipid accumulation in the liver. When the 3' and 4' positions are chlorinated, the relationship still holds but, for a constant number of chlorine atoms, the intensity of the effects are decreased. Fourteen days after hepatectomy, there was only a significant difference in the case of decachlorobiphenyl and Phenoclor DP5, for which the hypertrophy is accompanied by hyperplasia. The relationships are discussed between the chemical structure of the PCBs, their metabolization, their toxicity, and the reversibility of their effects.
研究了经胃内给予多氯联苯对部分肝切除（70%）大鼠的影响。肝切除术后7天，观察到联苯分子氯化程度的增加与肝脏肥大及脂质蓄积之间存在关联。当3'和4'位被氯化时，这种关系仍然成立，但对于相同数量的氯原子，效应强度会降低。肝切除术后14天，仅在十氯联苯和五氯酚DP5的情况下存在显著差异，其肥大伴有增生。讨论了多氯联苯的化学结构、代谢、毒性及其效应可逆性之间的关系。
