在冠心病患者中，联合使用α受体阻滞剂和β受体阻滞剂相较于单独使用β受体阻滞剂的血流动力学优势。
Haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone in patients with coronary heart disease.
作者信息
Taylor S H, Silke B, Nelson G I, Okoli R C, Ahuja R C
出版信息
Br Med J (Clin Res Ed). 1982 Jul 31;285(6338):325-7. doi: 10.1136/bmj.285.6338.325.
Abstract
The acute haemodynamic effects of beta-blockade with propranolol and combined alpha-blockade and beta-blockade with labetalol were compared in a randomised study in 12 patients with coronary artery disease proved by angiography. Propranolol induced significantly greater depression of left ventricular function both at rest and during exercise than labetalol. This difference was probably attributable to the vasodilator activity of labetalol and the associated reduction in afterload offsetting the haemodynamic disadvantages of blockade of cardiac beta-adrenoceptors alone. The haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone may thus have therapeutic implications for the use of these treatments in patients with coronary heart disease.
摘要
在一项随机研究中，对12例经血管造影证实患有冠状动脉疾病的患者，比较了普萘洛尔β受体阻滞剂和拉贝洛尔α受体阻滞剂与β受体阻滞剂联合应用的急性血流动力学效应。普萘洛尔在静息和运动时引起的左心室功能抑制均比拉贝洛尔明显更严重。这种差异可能归因于拉贝洛尔的血管舒张活性以及相关的后负荷降低，抵消了单独阻断心脏β肾上腺素能受体的血流动力学不利因素。因此，α受体阻滞剂与β受体阻滞剂联合应用相对于单独使用β受体阻滞剂的血流动力学优势，可能对冠心病患者使用这些治疗方法具有治疗意义。
相似文献
1
Haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone in patients with coronary heart disease.在冠心病患者中，联合使用α受体阻滞剂和β受体阻滞剂相较于单独使用β受体阻滞剂的血流动力学优势。
Br Med J (Clin Res Ed). 1982 Jul 31;285(6338):325-7. doi: 10.1136/bmj.285.6338.325.
2
Comparative haemodynamic dose response effects of propranolol and labetalol in coronary heart disease.普萘洛尔和拉贝洛尔对冠心病血流动力学剂量反应的比较效应
Br Heart J. 1982 Oct;48(4):364-71. doi: 10.1136/hrt.48.4.364.
3
4
Haemodynamic effects of combined alpha- and beta-adrenoreceptor blockade after intravenous labetalol in hypertensive patients at rest and during exercise.静脉注射拉贝洛尔后，α和β肾上腺素能受体联合阻断对高血压患者静息及运动时血流动力学的影响。
Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):725-8.
5
Pharmacology of combined alpha-beta-blockade. II. Haemodynamic effects of labetalol.α-β受体联合阻滞的药理学。II. 拉贝洛尔的血流动力学效应。
Drugs. 1984;28 Suppl 2:35-50. doi: 10.2165/00003495-198400282-00004.
6
alpha- and beta-blockade with labetalol in acute myocardial infarction.
J Cardiovasc Pharmacol. 1982 Nov-Dec;4(6):921-4. doi: 10.1097/00005344-198211000-00007.
7
A review of the animal pharmacology of labetalol, a combined alpha- and beta-adrenoceptor-blocking drug.拉贝洛尔（一种α和β肾上腺素受体阻断联合药物）的动物药理学综述。
Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):681-4.
8
Cardiovascular dynamics after acute and long-term alpha- and beta-adrenoceptor blockade at rest, supine and standing, and during exercise.急性和长期α及β肾上腺素能受体阻滞在静息、仰卧位、站立位以及运动期间对心血管动力学的影响。
Br J Clin Pharmacol. 1979;8(Suppl 2):101S-105S.
9
Haemodynamic effects of long-term oral labetalol.长期口服拉贝洛尔的血流动力学效应。
Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):733-6.
10
Comparison of haemodynamic dose-response effects of beta- and alpha-beta-blockade in acute myocardial infarction.
Int J Cardiol. 1984 Mar;5(3):317-25. doi: 10.1016/0167-5273(84)90109-8.
引用本文的文献
1
Drug therapy of chronic heart failure.慢性心力衰竭的药物治疗
Cardiovasc Drugs Ther. 1988 Nov;2(Suppl 1):407-412. doi: 10.1007/BF00633421.
2
Comparison of the hemodynamic effects of metoprolol and carvedilol in hypertensive patients.美托洛尔与卡维地洛对高血压患者血流动力学影响的比较。
Cardiovasc Drugs Ther. 1996 May;10(2):113-7. doi: 10.1007/BF00823588.
3
Pharmacokinetic and haemodynamic studies with labetalol in acute myocardial infarction.
Ir J Med Sci. 1983 May;152(5):179-86. doi: 10.1007/BF02954714.
4
Metabolic and haemodynamic effects of increased circulating adrenaline in man. Effect of labetalol, an alpha and beta blocker.人体循环肾上腺素增加的代谢和血流动力学效应。α和β受体阻滞剂拉贝洛尔的作用。
Br Heart J. 1983 Sep;50(3):277-81. doi: 10.1136/hrt.50.3.277.
5
Letter from . . . Chicago. Hard times in intensive care.来自……芝加哥的信。重症监护室的艰难时刻。
Br Med J (Clin Res Ed). 1983 Feb 26;286(6366):708-9. doi: 10.1136/bmj.286.6366.708.
6
Alpha- and beta-blockade in angina pectoris.心绞痛中的α和β受体阻滞剂
Drugs. 1984;28 Suppl 2:69-87. doi: 10.2165/00003495-198400282-00006.
7
Differences in haemodynamic response to beta-blocking drugs between stable coronary artery disease and acute myocardial infarction.
Eur J Clin Pharmacol. 1986;29(6):659-65. doi: 10.1007/BF00615955.
本文引用的文献
1
Effect of oral propranolol on rest and exercise left ventricular ejection fraction, volumes, and segmental wall motion in patients with angina pectoris. Assessment with equilibrium gated blood pool imaging.口服普萘洛尔对心绞痛患者静息和运动时左心室射血分数、容量及节段性室壁运动的影响。采用平衡门控心血池显像进行评估。
Br Heart J. 1981 Jun;45(6):656-66. doi: 10.1136/hrt.45.6.656.
2
One year's treatment with propranolol after myocardial infarction: preliminary report of Norwegian multicentre trial.心肌梗死后使用普萘洛尔进行一年治疗：挪威多中心试验的初步报告。
Br Med J (Clin Res Ed). 1982 Jan 16;284(6310):155-60. doi: 10.1136/bmj.284.6310.155.
3
Intravenous beta-blockade in coronary heart disease: is cardioselectivity or intrinsic sympathomimetic activity hemodynamically useful?冠心病中的静脉β受体阻滞剂：心脏选择性或内在拟交感活性在血流动力学上是否有用？
N Engl J Med. 1982 Mar 18;306(11):631-5. doi: 10.1056/NEJM198203183061102.
4
Haemodynamic effects of beta-blockade in ischaemic heart failure.β受体阻滞剂对缺血性心力衰竭的血流动力学影响。
Lancet. 1981 Oct 17;2(8251):835-7. doi: 10.1016/s0140-6736(81)91105-3.
5
Early intravenous atenolol treatment in suspected acute myocardial infarction. Preliminary report of a randomised trial.疑似急性心肌梗死患者早期静脉注射阿替洛尔治疗。一项随机试验的初步报告。
Lancet. 1980 Aug 9;2(8189):273-6. doi: 10.1016/s0140-6736(80)90231-7.
6
Velocity of contraction as a determinant of myocardial oxygen consumption.收缩速度作为心肌耗氧量的一个决定因素。
Am J Physiol. 1965 Nov;209(5):919-27. doi: 10.1152/ajplegacy.1965.209.5.919.
7
Thirteenth Bowditch lecture. The determinants of myocardial oxygen consumption.第十三届鲍迪奇讲座。心肌耗氧量的决定因素。
Physiologist. 1969 May;12(2):65-93.
8
Effects of beta adrenergic blockade on heart size.β肾上腺素能阻滞剂对心脏大小的影响。
Am J Cardiol. 1966 Sep;18(3):321-8. doi: 10.1016/0002-9149(66)90049-x.
9
Effect of propranolol on left ventricular function, segmental wall motion, and diastolic pressure-volume relation in man.普萘洛尔对人体左心室功能、节段性室壁运动及舒张期压力-容积关系的影响。
Br Heart J. 1975 Apr;37(4):357-64. doi: 10.1136/hrt.37.4.357.
10
Comparison of the immediate effects of five beta-adrenoreceptor-blocking drugs with different ancillary properties in angina pectoris.五种具有不同辅助特性的β-肾上腺素能受体阻滞剂对心绞痛即时疗效的比较。
N Engl J Med. 1979 Apr 5;300(14):750-5. doi: 10.1056/NEJM197904053001402.
Zotero 插件