Taylor S H, Silke B, Nelson G I, Okoli R C, Ahuja R C
Br Med J (Clin Res Ed). 1982 Jul 31;285(6338):325-7. doi: 10.1136/bmj.285.6338.325.
The acute haemodynamic effects of beta-blockade with propranolol and combined alpha-blockade and beta-blockade with labetalol were compared in a randomised study in 12 patients with coronary artery disease proved by angiography. Propranolol induced significantly greater depression of left ventricular function both at rest and during exercise than labetalol. This difference was probably attributable to the vasodilator activity of labetalol and the associated reduction in afterload offsetting the haemodynamic disadvantages of blockade of cardiac beta-adrenoceptors alone. The haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone may thus have therapeutic implications for the use of these treatments in patients with coronary heart disease.
在一项随机研究中，对12例经血管造影证实患有冠状动脉疾病的患者，比较了普萘洛尔β受体阻滞剂和拉贝洛尔α受体阻滞剂与β受体阻滞剂联合应用的急性血流动力学效应。普萘洛尔在静息和运动时引起的左心室功能抑制均比拉贝洛尔明显更严重。这种差异可能归因于拉贝洛尔的血管舒张活性以及相关的后负荷降低，抵消了单独阻断心脏β肾上腺素能受体的血流动力学不利因素。因此，α受体阻滞剂与β受体阻滞剂联合应用相对于单独使用β受体阻滞剂的血流动力学优势，可能对冠心病患者使用这些治疗方法具有治疗意义。
