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[Production of an anti-digitalin monoclonal antibody (author's transl)].

作者信息

Edelman L, Colignon A, Scherrmann J M, Fournier E, Reviron J, Bach J F

出版信息

C R Seances Acad Sci III. 1982 Mar 8;294(10):421-4.

PMID:6807500
Abstract

Anti-digitalin monoclonal antibodies were obtained by hybridization of lymphoid cells from mice immunized with the drug and the 8653 myeloma cells from BALB/c Mice. Two of these antibodies were submitted to immunochemical analysis which revealed that they belonged to IgM and IgGl classes, and the high affinity of one of them (1,2 x 10(9) M(-1)). The availability os such antibodies opens new perspectives for the treatment of digitalin intoxication and the possibility of establishing a standardized radioimmunoassay.

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