Strayer D S, Kapp J
Clin Exp Immunol. 1982 Jan;47(1):77-84.
The murine antibody response to porcine insulin is controlled by immune response genes of the major histocompatibility complex. Animals of the one haplotype (H-2d) produce specific antibodies to pork insulin, while animals of other haplotypes do not. We analysed the antibody responses to purified pork insulin by animals of responder and non-responder haplotypes, and attempted to correlate these responses with histopathological findings at necropsy. Animals of responder and non-responder haplotypes immunized with insulin or control preparations generally presented similar pathological pictures. We found granulomatous inflammatory infiltrates in the liver and the periphery of the pancreas, mononuclear interstitial pancreatic infiltrates, and mononuclear hepatic pericholangitis. Those were ascribe to adjuvant. One animal (H-2d) immunized with insulin showed focal peri-insulitis. Otherwise, the inflammatory infiltrates in the islets reported by others were not observed. The significance of insulitis in experimental insulin immunity is discussed.
小鼠对猪胰岛素的抗体反应受主要组织相容性复合体免疫反应基因的控制。单倍型（H-2d）的动物会产生针对猪胰岛素的特异性抗体，而其他单倍型的动物则不会。我们分析了反应性和非反应性单倍型动物对纯化猪胰岛素的抗体反应，并试图将这些反应与尸检时的组织病理学发现相关联。用胰岛素或对照制剂免疫的反应性和非反应性单倍型动物通常呈现相似的病理图像。我们在肝脏和胰腺周边发现了肉芽肿性炎性浸润、单核细胞间质性胰腺浸润以及单核细胞性肝门管周炎。这些都归因于佐剂。一只用胰岛素免疫的动物（H-2d）出现了局灶性胰岛周炎。此外，未观察到其他人报道的胰岛炎。本文讨论了胰岛炎在实验性胰岛素免疫中的意义。
