Coutinho-Netto J, Boyar M M, Abdul-Ghani A S, Bradford H F
Epilepsia. 1982 Aug;23(4):383-9. doi: 10.1111/j.1528-1157.1982.tb05424.x.
The in vivo incorporation of [14C] from [U-14C]-glucose into rat brain proteins from different cortical areas was examined in three different experimental focal epilepsies: cobalt, freeze-lesions, and tityustoxin. When [U-14C]-glucose was injected intraperitoneally into awake and unrestrained animals with marked signs of epileptic hyperactivity, the inhibition of incorporation of [14C]-amino acids into trichloracetic acid (TCA)-insoluble proteins was highest in the focal (sensorimotor) area when compared with distant regions (approx. 60%), but less when compared with the contralateral (sensorimotor) region (approx. 23%). Greatly decreased incorporation caused by both cobalt and freeze-lesion-induced epilepsies was also observed in the contralateral area when a comparison was made with distant regions (approx. 50%), but there were no significant differences in protein-specific radioactivity between the different distant areas.
在三种不同的实验性局灶性癫痫（钴、冷冻损伤和泰攀蛇毒素）中，研究了[U-¹⁴C]-葡萄糖中的[¹⁴C]在体内掺入大鼠不同皮质区域脑蛋白的情况。当将[U-¹⁴C]-葡萄糖腹腔注射到有明显癫痫活动亢进迹象的清醒且不受约束的动物体内时，与远处区域相比，[¹⁴C]-氨基酸掺入三氯乙酸（TCA）不溶性蛋白的抑制在局灶性（感觉运动）区域最高（约60%），但与对侧（感觉运动）区域相比则较低（约23%）。与远处区域相比，钴和冷冻损伤诱导的癫痫在对侧区域也观察到掺入量大幅下降（约50%），但不同远处区域之间的蛋白特异性放射性没有显著差异。
