成年胸腺切除小鼠外周血淋巴细胞的[3H]胸苷标记动力学
[3H] thymidine labelling kinetics of peripheral blood lymphocytes in adult thymectomized mice.
作者信息
Harris G
出版信息
Immunology. 1978 Jun;34(6):1083-8.
Abstract
The appearance of labelled lymphocytes in the blood of adult thymectomized mice was followed for 21 days after a single injection of [3H] thymidine. The results showed that the expected changes in their life-span resulting from thymic deprivation were not reflected in the kinetics of labelling of these cells with this radioactively-labelled precursor for DNA synthesis. Turnover of DNA and exchange of label between cells must be considered in relation to the results, as had been previously concluded from similar studies of intact mice (Harris, 1975a).
摘要
在成年去胸腺小鼠单次注射[3H]胸腺嘧啶核苷后，对血液中标记淋巴细胞的出现情况进行了21天的跟踪观察。结果显示，胸腺缺失导致的预期寿命变化并未反映在这些细胞用这种放射性标记的DNA合成前体进行标记的动力学过程中。正如之前对完整小鼠的类似研究所得出的结论（哈里斯，1975a），在考虑这些结果时，必须兼顾DNA的周转以及细胞间标记的交换情况。
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