Cooper P H, Novin D, Butcher L L
Neurosci Lett. 1982 May 17;30(1):13-8. doi: 10.1016/0304-3940(82)90004-0.
Extensive extravasation of intravenously administered horseradish peroxidase (HRP) was observed in rat brains infused intranigrally with 8 microgram/4 microliter or 4 microgram/2 microliter 6-hydroxydopamine (6-OHDA), suggesting that the cytotoxin produced widespread alterations in the integrity of the blood-brain barrier. Such damage was dose-dependent and occurred in the mesencephalon around the cannula tip, along the cannula tract, and in the cerebral cortex. The extent of HRP extravasation diminished as a function of increasing time after 6-OHDA administration. These findings indicate that alterations in blood-brain barrier permeability may contribute to the constellation of dysfunctions and possible recovery of function following intranigral infusions of the cytotoxin.
在向大鼠脑黑质内注射8微克/4微升或4微克/2微升6-羟基多巴胺（6-OHDA）后，观察到静脉注射的辣根过氧化物酶（HRP）出现大量外渗，这表明细胞毒素导致血脑屏障完整性发生广泛改变。这种损伤具有剂量依赖性，发生在插管尖端周围的中脑、沿插管通道以及大脑皮层。HRP外渗的程度随着6-OHDA给药后时间的增加而降低。这些发现表明，血脑屏障通透性的改变可能导致细胞毒素脑黑质内注射后出现的一系列功能障碍以及可能的功能恢复。
