人牙龈体外培养中女性性激素浓度与前列腺素产生之间的关系。

The relationship between the concentration of female sex steroids and prostaglandins production by human gingiva in vitro.

作者信息

ElAttar T M, Lin H S, Tira D E

出版信息

Prostaglandins Leukot Med. 1982 May;8(5):447-58.

Abstract

The relationship between various concentrations of estradiol-17 beta and progesterone, alone and in combination, and the formation of radioactive prostaglandins (PGs) from 14C-arachidonic acid by gingival homogenate has been investigated. There was a statistically significant negative linear trend between each of the hormone treatments at concentrations of 10(-9), 10(-7), 10(-5) and 10(-3)M and the amounts of 6-keto-PGF1a, PGF2a, PGE2, PGD2 and 15-keto-PGE2 formed. Each of estradiol-17 beta and progesterone at 10(-9) and 10(-7)M exerted stimulatory effect, whereas at higher concentrations they had an inhibitory effect on all PGs tested. These observations suggest that the concentration of female sex hormones is an important factor in regulating PG biosynthesis by gingival tissue.

摘要

研究了不同浓度的雌二醇 - 17β和孕酮单独及联合作用时，与牙龈匀浆从14C - 花生四烯酸形成放射性前列腺素（PGs）之间的关系。在10(-9)、10(-7)、10(-5)和10(-3)M浓度下，每种激素处理与6 - 酮 - PGF1a、PGF2a、PGE2、PGD2和15 - 酮 - PGE2的生成量之间均存在统计学上显著的负线性趋势。10(-9)和10(-7)M的雌二醇 - 17β和孕酮均发挥刺激作用，而在较高浓度时，它们对所有测试的PGs均有抑制作用。这些观察结果表明，女性性激素浓度是调节牙龈组织PG生物合成的一个重要因素。