McGillkiard K L, Jones S E, Robertson G E, Olsen G D
Respir Physiol. 1982 Mar;47(3):299-311. doi: 10.1016/0034-5687(82)90059-7.
Respiratory studies were conducted on newborn puppies chronically exposed to alpha-l-acetylmethadol . HCl (LAAM) during portions of gestation. Bitches received daily oral doses of LAAM from the second week through the sixth week of pregnancy (LAAM-6) or through the end of a 9-week pregnancy (LAAM-9), but not after parturition. LAAM-9 pups displayed narcotic abstinence signs during the first week after birth, while LAAM-6 pups did not. LAAM-9 pups had increased tidal volume, respiratory frequency, alveolar ventilation and O2-consumption and decreased alveolar CO2-tension during the first week of life compared to placebo-treated controls. The LAAM-9 CO2-response curve was significantly displaced to the left of control. These data are consistent with relative hyperventilation during neonatal withdrawal from LAAM. LAAM-6 pups had decreased tidal volume and alveolar ventilation during 4 of the 6 weeks studied. These changes in ventilation were associated with a decrease in O2 consumption. By 6 weeks after birth CO2-response curves of both LAAM-9 and LAAM-6 pups were shifted to the right of control. These changes in CO2-responsiveness suggest the possibility of prolonged disturbances of respiratory control which may continue beyond the sixth week of life.
对在孕期部分时间长期接触盐酸α-1-乙酰美沙醇（LAAM）的新生幼犬进行了呼吸研究。母犬在怀孕的第二周直至第六周（LAAM-6组）或整个9周孕期（LAAM-9组）接受每日口服LAAM，但产后不再给药。LAAM-9组幼犬在出生后的第一周出现了戒断症状，而LAAM-6组幼犬没有。与安慰剂处理的对照组相比，LAAM-9组幼犬在出生后的第一周潮气量、呼吸频率、肺泡通气量和耗氧量增加，肺泡二氧化碳张力降低。LAAM-9组的二氧化碳反应曲线明显向对照组左侧偏移。这些数据与新生儿从LAAM戒断期间的相对过度通气一致。在研究的6周中的4周，LAAM-6组幼犬的潮气量和肺泡通气量降低。这些通气变化与耗氧量减少有关。到出生后6周时，LAAM-9组和LAAM-6组幼犬的二氧化碳反应曲线均向对照组右侧偏移。这些二氧化碳反应性的变化表明呼吸控制可能会长期受到干扰，这种干扰可能会持续到出生后第六周以后。
