Miyazawa T, Hiramoto M, Hiramoto T, Nishida O
Respir Physiol. 1982 Mar;47(3):351-64. doi: 10.1016/0034-5687(82)90063-9.
The effects of Prostacyclin (PGI2) on gas exchange were investigated in 13 adult mongrel dogs with acute pulmonary edema induced by oleic acid (0.09 ml/kg). The time course of changes in gas exchange was measured during spontaneous ventilation with room air. In the Control group, with oleic acid induced respiratory distress, there were marked decreases in arterial PO2 and PCO2, and marked increases in respiratory frequency, expired minute volume, alveolar (end tidal)-arterial PO2 difference, arterial-alveolar (end tidal) PCO2 difference and physiological dead space to tidal volume ratio. In the Test group, respiratory distress was also induced by the oleic acid injection, however, subsequent infusion of PGI2 (200 ng/kg/min) reversed the values of these parameters, which were significantly different from those in the Control group. The results suggest that PGI2 has a protective action against impairment of gas exchange in the presence of increased pulmonary vascular permeability.
在13只由油酸（0.09毫升/千克）诱发急性肺水肿的成年杂种犬中，研究了前列环素（PGI2）对气体交换的影响。在吸入室内空气进行自主通气期间，测量气体交换变化的时间过程。在对照组中，油酸诱发呼吸窘迫，动脉血氧分压（PO2）和二氧化碳分压（PCO2）显著降低，呼吸频率、每分钟呼出量、肺泡（呼气末）-动脉血氧分压差、动脉-肺泡（呼气末）二氧化碳分压差以及生理死腔与潮气量比值显著增加。在试验组中，注射油酸也诱发了呼吸窘迫，然而，随后输注前列环素（200纳克/千克/分钟）使这些参数的值发生逆转，与对照组有显著差异。结果表明，在肺血管通透性增加的情况下，前列环素对气体交换受损具有保护作用。
