Mehlhorn H, Moltmann U, Schein E, Voigt W P
Tropenmed Parasitol. 1981 Dec;32(4):231-3.
The effect of halofuginone (Stenorol) on schizonts of Theileria parva was studied by means of the electron microscope. After administration of 1,2 mg halofuginone per kg, it was observed that infected lymphocytes burst apart, whereas the intracellular parasites were at first little affected, showing some expansion of the perinuclear spaces. Once they were released from the cells, the schizonts degenerated completely. Apparently they are not capable of surviving outside the host cells. Probably this is due to the lack of a pellicle, which is characteristic for motile (i.e. normally extracellular) stages. The destruction of parasitized host cells occurred very rapidly, so that no infected cells could be observed 126 h after treatment. Uninfected lymphocytes were not affected by the drug.
通过电子显微镜研究了卤夫酮（速眠新）对小泰勒虫裂殖体的作用。每千克体重给予1.2毫克卤夫酮后，观察到受感染的淋巴细胞破裂，而细胞内的寄生虫起初受影响较小，仅核周间隙略有扩大。一旦它们从细胞中释放出来，裂殖体就会完全退化。显然，它们无法在宿主细胞外存活。这可能是由于缺乏动基体（即通常为细胞外阶段）特有的表膜。被寄生的宿主细胞的破坏非常迅速，以至于在治疗后126小时无法观察到受感染的细胞。未受感染的淋巴细胞不受该药物影响。
