Hermansen M C, Ellison P H
Ann Neurol. 1982 Apr;11(4):344-6. doi: 10.1002/ana.410110404.
In adults, cerebrospinal fluid (CSF) acid-base balance is an important determinant of cerebral blood flow, ventilatory drive, and state of consciousness. Sixteen lumbar punctures were performed on newborns (mean gestational age, 33.8 weeks; range, 26 to 44 weeks). The mean CSF pH was 7.366 units, 0.036 less than the mean capillary blood pH (NS). The mean CSF arterial carbon dioxide tension (PCO2) was 40.3 mm Hg, 6.7 greater than the mean blood PCO2 (p less than 0.01). The mean bicarbonate ion concentration in CSF was 21.8 mEq/L, 1.2 greater than that in blood (NS). Acid-base determinations in CSF of neonates with intraventricular hemorrhage did not differ significantly from those of neonates with otherwise normal CSF. These acid-base values are similar to those found in adults and did not vary with gestational age, suggesting that mechanisms to establish this acid-base gradient are developed by 26 weeks' gestation.
在成年人中，脑脊液（CSF）酸碱平衡是脑血流量、通气驱动和意识状态的重要决定因素。对新生儿进行了16次腰椎穿刺（平均胎龄33.8周；范围26至44周）。脑脊液平均pH值为7.366单位，比平均毛细血管血pH值低0.036（无显著性差异）。脑脊液动脉二氧化碳分压（PCO2）平均为40.3 mmHg，比平均血PCO2高6.7（p<0.01）。脑脊液中碳酸氢根离子平均浓度为21.8 mEq/L，比血液中高1.2（无显著性差异）。脑室出血新生儿脑脊液的酸碱测定结果与脑脊液正常的新生儿无显著差异。这些酸碱值与成年人相似，且不随胎龄变化，提示建立这种酸碱梯度的机制在妊娠26周时已发育形成。
