Shinohara Y, Takagi S, Kobatake K, Gotoh F
Arch Neurol. 1982 Aug;39(8):479-81. doi: 10.1001/archneur.1982.00510200021003.
The influence of cerebral venous obstruction on cerebral circulation was investigated in three patients with cerebral venous and sinus thrombosis in the chronic stage. The xenon Xe 133 intracarotid injection method was used to evaluate the cerebral blood flow (CBF). Values for CBF showed a slight decrease in all patients, despite intact cerebrovascular autoregulation. In two of the three patients, hypercapnia failed to increase CBF, but hyperventilation decreased CBF normally. This phenomenon can be explained on the basis of both failure of the capacitance vessels on the venous side to dilate and an increased intracranial pressure and is not attributable to decreased carbon dioxide reactivity. Long-lasting obstruction of the venous system can lead to a slight reduction in CBF and not affect cerebral autoregulation or CO2 reactivity itself in humans.
在3例慢性期脑静脉和静脉窦血栓形成的患者中，研究了脑静脉阻塞对脑循环的影响。采用氙Xe 133颈动脉注射法评估脑血流量（CBF）。尽管脑血管自动调节功能完好，但所有患者的CBF值均略有下降。在3例患者中的2例中，高碳酸血症未能增加CBF，但过度通气正常地降低了CBF。这种现象可以基于静脉侧容量血管扩张失败和颅内压升高来解释，而不是由于二氧化碳反应性降低。静脉系统的长期阻塞可导致CBF略有降低，且不影响人体的脑自动调节或二氧化碳反应性本身。
