Gomes M A, Dambuyant C, Thivolet J, Bussy R
Br J Dermatol. 1982 Jul;107(1):43-51. doi: 10.1111/j.1365-2133.1982.tb00288.x.
Twenty bullous pemphigoid (BP) patients were studied to establish any correlation between free anti-basement membrane zone (BMZ) antibodies, circulating immune complexes (CIC) and dermo-epidermal junction deposits. CIC levels were evaluated by 2% polyethylene glycol (PEG) precipitation. The twenty patients were found to have IgG and/or C3 deposited in the BMZ. Eight of the twelve patients who had no free anti-BMZ antibodies displayed a positive in vivo C4 and/or CIq staining and high levels of CIC. Moreover, CIC were detected in only one patient with positive circulating free anti-BMZ antibodies. The presence of free anti-BMZ antibodies was generally found to correlate with the absence of cutaneous deposits of CIq and /or C4 and with negative CIC; on the other hand, the absence of free anti-BMZ antibodies was generally found to correlate with high levels of CIC and with deposits of C3 and CIq and/or C4. The absence of circulating free anti-BMZ antibodies in BP patients, could be explained by the formation of CIC. It is possible that BMZ antigens released from damaged tissue could combine with free antibodies and form complexes in the blood. The release could involve locally formed immune complexes. Elevated CIC levels were generally found to correlate with the presence of active disease.
对20例大疱性类天疱疮（BP）患者进行了研究，以确定游离抗基底膜带（BMZ）抗体、循环免疫复合物（CIC）与真皮-表皮交界处沉积物之间是否存在任何相关性。通过2%聚乙二醇（PEG）沉淀法评估CIC水平。发现这20例患者在BMZ中有IgG和/或C3沉积。在12例无游离抗BMZ抗体的患者中，有8例在体内C4和/或CIq染色呈阳性且CIC水平较高。此外，仅在1例循环游离抗BMZ抗体呈阳性的患者中检测到CIC。一般发现游离抗BMZ抗体的存在与CIq和/或C4的皮肤沉积物缺失以及CIC阴性相关；另一方面，一般发现无游离抗BMZ抗体与CIC高水平以及C3和CIq和/或C4沉积物相关。BP患者循环游离抗BMZ抗体的缺失可能是由CIC的形成所解释的。受损组织释放的BMZ抗原可能与游离抗体结合并在血液中形成复合物。这种释放可能涉及局部形成的免疫复合物。一般发现CIC水平升高与活动性疾病的存在相关。
