光适应大鼠视网膜多巴胺能神经元活动对黑暗的适应性
Adaptation of retinal dopamine neuron activity in light-adapted rats to darkness.
作者信息
Proll M A, Morgan W W
出版信息
Brain Res. 1982 Jun 10;241(2):359-61. doi: 10.1016/0006-8993(82)91078-2.
PMID:6809228
Abstract
The activity of the retinal dopamine neurons was studied in light-adapted rats exposed to darkness for periods ranging from 10 min to 15 h. Dihydroxyphenylalanine (DOPA) accumulation, following inhibition of L-aromatic amino acid decarboxylase with NSD-1015, was used as an index of dopamine neuronal activity. After only 10 min of darkness, DOPA accumulation had decreased to levels found in rats dark-adapted for 15 h.
摘要
在光照适应的大鼠中，研究了其视网膜多巴胺神经元在暴露于黑暗中10分钟至15小时期间的活动。用NSD - 1015抑制L - 芳香族氨基酸脱羧酶后，二羟基苯丙氨酸（DOPA）的积累被用作多巴胺神经元活动的指标。仅在黑暗10分钟后，DOPA积累就已降至适应黑暗15小时的大鼠中的水平。
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