鸟氨酸脱羧酶不可逆抑制剂DL-α-二氟甲基鸟氨酸对大鼠排卵的促进作用。
Enhancement of ovulation in the rat by DL-alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
作者信息
Carpenter J R, Fozard J R
出版信息
Eur J Pharmacol. 1982 May 21;80(2-3):263-6. doi: 10.1016/0014-2999(82)90066-8.
Spontaneously cycling Sprague-Dawley Rats were treated with the irreversible ornithine decarboxylase (ODC) inhibitor DL-alpha-difluoromethylornithine (DFMO) on the day of proestrus. This treatment completely suppressed both the rise in ovarian ODC and the associated increase in putrescine concentration and increased the number of eggs released the next day by 91%. At the next oestrus (5 days after DFMO) there was a increase of 53% but at the third oestrus after DFMO (9 days) there was no significant change in the number of eggs released. A model is proposed in which ornithine decarboxylase forms part of a local inhibitory feed-back system controlling the number of follicles which develop to maturity and rupture during each cycle.
在动情前期当天，对自发周期循环的斯普拉格-道利大鼠使用不可逆的鸟氨酸脱羧酶（ODC）抑制剂DL-α-二氟甲基鸟氨酸（DFMO）进行处理。这种处理完全抑制了卵巢ODC的升高以及腐胺浓度的相关增加，并使第二天排出的卵子数量增加了91%。在下一个发情期（DFMO处理后5天），卵子数量增加了53%，但在DFMO处理后的第三个发情期（9天），排出的卵子数量没有显著变化。提出了一个模型，其中鸟氨酸脱羧酶构成局部抑制性反馈系统的一部分，该系统控制每个周期中发育成熟并破裂的卵泡数量。
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