Kaneda T, Shikimori M, Watanabe I, Minato F, Koide Y, Inoue N, Oka T
Int J Oral Surg. 1981 Aug;10(4):266-71. doi: 10.1016/s0300-9785(81)80070-1.
Deficient coagulation factor replacement therapy is often indispensable for dental extractions and oral mucosal bleeding in hemophiliac patients. High concentrates are often infused in large amounts of volume, until complete hemostasis is achieved. Considering the various side effects of replacement therapy the volume infused should be reduced to a minimum. Several aspects associated with replacement therapy for the control of oral bleeding are studied. Our conclusion is that local hemostatic procedures are even more important than replacement therapy. The use of surgical packs and band retainers proved to be of benefit in this study.
对于血友病患者的拔牙和口腔黏膜出血，凝血因子替代疗法不足时通常必不可少。高浓缩物常大量输注，直至实现完全止血。考虑到替代疗法的各种副作用，应将输注量减至最小。研究了与替代疗法控制口腔出血相关的几个方面。我们的结论是，局部止血程序甚至比替代疗法更重要。在本研究中，手术包和带环保持器的使用被证明是有益的。
