精神分裂症和分裂情感性障碍患者的锂神经毒性。神经毒性与行为状态相关的方面。

Lithium neurotoxicity in schizophrenic and schizoaffective patients. Behavioral state-related aspects of neurotoxicity.

作者信息

West A P

出版信息

Int Pharmacopsychiatry. 1982;17(2):91-103. doi: 10.1159/000468562.

Abstract

A large variability in the rates of lithium-induced toxic-confusional states is noted in studies of lithium treatment of schizophrenic and schizoaffective patients. Treatment and subject factors which might contribute to this variability are reviewed. A greater frequency of lithium-induced toxic-confusional states is found in more acutely ill schizophrenic and schizoaffective patients. The possibility that some behavioral states may increase the risk for lithium neurotoxicity is discussed.

摘要

在对精神分裂症和分裂情感性障碍患者进行锂盐治疗的研究中，发现锂盐所致中毒性意识模糊状态的发生率存在很大差异。本文回顾了可能导致这种差异的治疗因素和个体因素。在病情更严重的精神分裂症和分裂情感性障碍患者中，锂盐所致中毒性意识模糊状态的发生率更高。文中还讨论了某些行为状态可能增加锂盐神经毒性风险的可能性。