Nurmi T
J Immunogenet. 1982 Jun;9(3):155-63. doi: 10.1111/j.1744-313x.1982.tb00786.x.
The following attributes of the immune response were studied from nine patients with different numbers of X chromosomes: serum immunoglobulin levels, C3 and C4 concentrations, the presence of autoantibodies, phagocytosis, killing of bacteria, the chemotactic response of neutrophils, the in vitro response of lymphocytes to PHA, ConA, PwM, PPD and oidiomycin; and the proportion of T lymphocytes was determined. The number of X chromosomes varied from one (45,X) to four (48,XXXX). No evidence of severe dysfunction in the immune system was found in any of the patients. The correlation coefficients between the serum concentration of IgM and IgG and the number of X chromosomes present were statistically significant (r = 0.691, P less than 0.05, and r = 0.714, P less than 0.05, respectively). The serum IgA concentration showed a tendency towards a negative correlation. The concentrations of neither IgD nor IgE correlated to the number of X chromosomes. It seems obvious that the number of X chromosomes is positively associated with the concentration of serum IgG and IgM. The results support the hypothesis that antibody production is at least partially controlled by genes located in the X chromosome.
对9名具有不同数量X染色体的患者的免疫反应的以下特征进行了研究：血清免疫球蛋白水平、C3和C4浓度、自身抗体的存在、吞噬作用、细菌杀伤、中性粒细胞的趋化反应、淋巴细胞对PHA、ConA、PwM、PPD和杀稻瘟菌素的体外反应；并测定了T淋巴细胞的比例。X染色体的数量从1条（45,X）到4条（48,XXXX）不等。在任何患者中均未发现免疫系统严重功能障碍的证据。血清IgM和IgG浓度与存在的X染色体数量之间的相关系数具有统计学意义（分别为r = 0.691，P < 0.05，以及r = 0.714，P < 0.05）。血清IgA浓度呈负相关趋势。IgD和IgE的浓度均与X染色体数量无关。显然，X染色体的数量与血清IgG和IgM的浓度呈正相关。这些结果支持了抗体产生至少部分受位于X染色体上的基因控制这一假说。
