Adinolfi M, Haddad S A, Seller M J
J Immunogenet. 1978 Jun;5(3):149-56. doi: 10.1111/j.1744-313x.1978.tb00640.x.
The levels of IgM were measured in sera from mice with different chromosome complements, including 39,XO mice and phenotypically male mice bearing the sex-reversed gene (Sxr) (XX,Sxr/+ and XY,Sxr/+). The mean values of IgM were found to be higher in normal female mice than in the males belonging to two different strains. This is in agreement with the higher mean serum levels of IgM observed in two groups of sera from normal human females and males. However, while we could confirm that the mean level of IgM was lower in 45,XO women than in normal females and comparable to the mean value of normal males, the same effect was not seen in 39,XO mice. In fact, the mean concentration of serum IgM in 39,XO mice was similar to that in normal females. Furthermore, it was observed that the mean values of serum IgM in the two groups of sex-reversed male mice (XX,Sxr/+ and XY,Sxr/+) were also not statistically different from those in normal males. Thus the role that the number of X chromosomes plays in the control of the serum levels of IgM is different in man and the mouse, in agreement with the observed different phenotypic manifestations, and in particular with the hormonal situations existing in X chromosome abnormalities in these two species.
在具有不同染色体组成的小鼠血清中测量了IgM水平，包括39,XO小鼠以及携带性别反转基因（Sxr）的表型为雄性的小鼠（XX,Sxr/+和XY,Sxr/+）。发现正常雌性小鼠的IgM平均值高于属于两种不同品系的雄性小鼠。这与在正常人类女性和男性的两组血清中观察到的较高的IgM平均血清水平一致。然而，虽然我们可以确认45,XO女性的IgM平均水平低于正常女性且与正常男性的平均值相当，但在39,XO小鼠中未观察到相同的效果。事实上，39,XO小鼠血清IgM的平均浓度与正常雌性小鼠相似。此外，观察到两组性别反转雄性小鼠（XX,Sxr/+和XY,Sxr/+）的血清IgM平均值与正常雄性小鼠的平均值在统计学上也没有差异。因此，X染色体数量在控制血清IgM水平中所起的作用在人类和小鼠中是不同的，这与观察到的不同表型表现一致，特别是与这两个物种X染色体异常中存在的激素情况一致。
