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一个法国家庭中ABO血型的非典型遗传

Atypical transmission of ABO blood groups in a French family.

作者信息

Badet J, Lopez M, Habibi B, Cartron J P, Noel A, Salmon D, Seger J, Salmon C

出版信息

J Immunogenet. 1982 Jun;9(3):169-77. doi: 10.1111/j.1744-313x.1982.tb00788.x.

DOI:10.1111/j.1744-313x.1982.tb00788.x
PMID:6809837
Abstract

A group AB mother (Mrs P.D.) gave birth to a group O female baby (C.D.). Extensive study of the blood group genetic markers in both the parents and the child, carried out on several occasions, showed nothing unusual outside the ABO system. Mrs P.D. then, gave birth to a second female baby who was also group O. Mrs P.D. had normal amounts of A, B, H and Lewis antigens in her saliva. The H, A and B agglutinability of her red cells was in the range of normal A2B group. This A2B blood group was characterized by very low A gene-specified glycosyltransferase activity in serum. Moreover this activity was undetectable in red blood cell membranes. These results are discussed in the light of various hypotheses in order to explain this unusual transmission of ABO blood group.

摘要

一位AB血型的母亲(P.D.夫人)生下了一个O型血的女婴(C.D.)。对父母和孩子的血型遗传标记进行了多次广泛研究,结果显示在ABO系统之外没有任何异常。随后,P.D.夫人又生下了一个同样是O型血的女婴。P.D.夫人唾液中的A、B、H和Lewis抗原含量正常。她红细胞的H、A和B凝集性处于正常A2B血型范围内。这种A2B血型的特点是血清中A基因特异性糖基转移酶活性非常低。此外,在红细胞膜中未检测到这种活性。根据各种假设对这些结果进行了讨论,以解释ABO血型这种不寻常的遗传情况。

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