Gubb D, García-Bellido A
J Embryol Exp Morphol. 1982 Apr;68:37-57.
The polarity mutants pk, sple, mwh, fz and in alter the orientations of cuticular processes in several regions of the body. The mutant polarity patterns are constant and do not result from alterations in cell lineage. Polarity patterns are locus specific rather than allele specific (new alleles express the same polarity patterns as the original alleles). In the wing, polarity formation is largely cell autonomous and is independent of the anteroposterior compartment boundary. By genetic and physiological manipulation it is shown that the mutant polarity patterns are unaffected by the size of the wing blade or the number of cells that form it. Mutants which remove parts of the wing margin or alter the distribution pattern of wing veins do not alter the mutant polarity patterns. Thus, neither the wing margins nor the pattern of vein tissue act as spatial references for polarity formation. The determination of mutant polarity patterns is not dependent on the overall topology of the wing blade but is region-specific. The mutants affect several independent functions. The possible wild-type function of the loci in polarity formation is discussed.
极性突变体pk、sple、mwh、fz和in改变了身体几个部位表皮突起的方向。突变体的极性模式是恒定的，并非由细胞谱系的改变所致。极性模式是基因座特异性而非等位基因特异性的（新等位基因表现出与原始等位基因相同的极性模式）。在翅膀中，极性形成在很大程度上是细胞自主的，并且独立于前后隔室边界。通过遗传和生理操作表明，突变体的极性模式不受翼片大小或形成它的细胞数量的影响。去除部分翼缘或改变翅脉分布模式的突变体不会改变突变体的极性模式。因此，翼缘和脉组织模式都不作为极性形成的空间参考。突变体极性模式的确定不依赖于翼片的整体拓扑结构，而是区域特异性的。这些突变体影响几种独立的功能。讨论了这些基因座在极性形成中可能的野生型功能。
