阴道用杀精剂与淋病

Vaginal spermicides and gonorrhea.

作者信息

Jick H, Hannan M T, Stergachis A, Heidrich F, Perera D R, Rothman K J

出版信息

JAMA. 1982 Oct 1;248(13):1619-21.

Abstract

All positive cultures for neisseria gonorrhoeae recorded from Dec 20, 1978, through Dec 31, 1980, for women born between 1940 and 1960 were identified among members of Group Health Cooperative of Puget Sound, Seattle, and rates of gonorrhea were calculated for recent oral contraceptive users, recent vaginal spermicide users, and women with surgical sterilization. The risk ratio (RR) estimate, based on the included population, for spermicide users compared with all others was 0.23 (90% confidence interval [Cl], 0.10, 0.50). When women with positive cultures for N gonorrhoeae were compared with women with negative cultures, the RR estimate comparing spermicide users with all others was 0.13 (90% Cl, 0.05, 0.34). The results are consistent with the protective effect of vaginal spermicides against gonorrhea.

摘要

对1978年12月20日至1980年12月31日期间记录的所有淋病奈瑟菌阳性培养物进行了鉴定，这些培养物来自西雅图普吉特海湾卫生合作组织中出生于1940年至1960年之间的女性，并计算了近期口服避孕药使用者、近期阴道杀精剂使用者以及接受手术绝育的女性的淋病发病率。基于纳入人群，杀精剂使用者与所有其他女性相比的风险比（RR）估计值为0.23（90%置信区间[Cl]，0.10，0.50）。当将淋病奈瑟菌培养阳性的女性与培养阴性的女性进行比较时，杀精剂使用者与所有其他女性相比的RR估计值为0.13（90%Cl，0.05，0.34）。结果与阴道杀精剂对淋病的保护作用一致。