Siegel M I, McConnell R T, Brent D A, Chandrasurin P, Macfarlane R D, McNeal C J
Mol Pharmacol. 1982 May;21(3):688-93.
Neutrophils isolated from the pleural cavity of rats 3 hr after the intrapleural injection of carrageenan metabolize exogenously added arachidonic acid via cyclooxygenase and lipoxygenase. In addition, these cells esterify arachidonic acid to produce diarachidonyl diglyceride. The structure of the diglyceride was determined with the use of various chemical and enzymatic digestions, gas chromatography-mass spectrometry, and 252Cf plasma-desorption mass spectrometry. The formation of this unique diglyceride is stimulated by the presence of nonsteroidal anti-inflammatory drugs. Some of the possible consequences of diarachidonyl diglyceride production are discussed.
在大鼠胸膜腔内注射角叉菜胶3小时后，从其胸膜腔分离出的中性粒细胞通过环氧化酶和脂氧合酶代谢外源性添加的花生四烯酸。此外，这些细胞将花生四烯酸酯化以生成二花生四烯酸甘油二酯。通过各种化学和酶消化、气相色谱-质谱联用以及252Cf等离子体解吸质谱法确定了甘油二酯的结构。非甾体抗炎药的存在会刺激这种独特甘油二酯的形成。文中讨论了二花生四烯酸甘油二酯产生的一些可能后果。
