Deforges L, Le Van Thoi J, Soussy C J, Duval J
Pathol Biol (Paris). 1982 Jun;30(6):363-9.
This work report a study of antibacterial activity of eight third generation cephalosporins : cefotaxime, moxalactam, cefoperazone, cefotiam, ceftazidime, ceftriaxone, cefmenoxime and cefotetan. The essential interest of these antibiotics is their activity against Enterobacteriaceae resistant to cefalothin ; however, five of them are clearly superior ; cefotaxime, moxalactam, cefmenoxime, ceftriaxone and ceftazidime. Ceftazidime is the best against Pseudomonas aeruginosa and moxalactam against the Bacteroides group. Against others bacterial groups, these new cephalosporins are not superior to former products.
本工作报告了对8种第三代头孢菌素的抗菌活性研究：头孢噻肟、拉氧头孢、头孢哌酮、头孢替安、头孢他啶、头孢曲松、头孢甲肟和头孢替坦。这些抗生素的主要优势在于它们对耐头孢噻吩的肠杆菌科细菌具有活性；然而，其中5种明显更具优势，即头孢噻肟、拉氧头孢、头孢甲肟、头孢曲松和头孢他啶。头孢他啶对铜绿假单胞菌的抗菌效果最佳，拉氧头孢对拟杆菌属的抗菌效果最佳。对于其他细菌群，这些新型头孢菌素并不比以前的产品更具优势。
