[双膦酸盐结合钙的能力及其对蛙膀胱壁渗透通透性的影响]
[Capacity of diphosphonates to bind calcium and their effect on the osmotic permeability of the frog bladder wall].
作者信息
Shakhmatova E I, Kabachnik M I, Medved' T Ia, Natochin Iu V
出版信息
Biull Eksp Biol Med. 1982 Jun;93(6):71-4.
PMID:6810972
Abstract
Like EDTA, diphosphonates increase permeability of the frog urinary bladder wall for water osmotic gradient. Their effect is proportional to the stability of their binding with calcium ions. The efficacy of diphosphonates falls upon pH decline. The results indicate the significance of Ca binding in cells and membrane action of diphosphonates.
摘要
与乙二胺四乙酸（EDTA）一样，双膦酸盐会因水渗透梯度而增加青蛙膀胱壁的通透性。它们的作用与其与钙离子结合的稳定性成正比。随着pH值下降，双膦酸盐的功效会降低。这些结果表明了细胞中钙结合以及双膦酸盐膜作用的重要性。
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