Corwin J, Schwartz B
Invest Ophthalmol Vis Sci. 1978 Aug;17(8):814-7.
This study examined the possibility that homologous limbal tissue, including trabecular meshwork, serving as an antigen, could elicit inflammatory cells responsible for both aqueous obstruction and inflammation; the possible role of this response in ocular disease was also studied. Four sets of guinea pigs were sensitized with complete Freund's adjuvant. One set received just adjuvant and saline, one set received adjuvant plus uvea, and two sets received adjuvant plus limbal tissue. The animal injected with only adjuvant and saline all showed normal ocular histology. Sensitizing guinea pigs with limbus and adjuvant produced mononuclear infiltration of the uvea, trabeculum, and episclera. Lymphocytes and plasma cells predominated. The response induced by the limbus seemed to consist of two components: a uveal and a specific limbal component. The lymphoid infiltration of the uvea was identical to the response induced by uveal antigen in our uvea control group. The limbal component was characterized by clusters of lymphocytes and plasma cells in the trabecular and episcleral regions. This study showed that limbal tissue antigen induces an inflammatory response in both uvea and limbus, and that the inflammatory response in the trabeculum is greater with limbal than uveal antigen.
本研究探讨了包括小梁网在内的同源角膜缘组织作为抗原引发导致房水阻塞和炎症的炎性细胞的可能性；还研究了这种反应在眼部疾病中的可能作用。四组豚鼠用完全弗氏佐剂致敏。一组仅接受佐剂和生理盐水，一组接受佐剂加葡萄膜，两组接受佐剂加角膜缘组织。仅注射佐剂和生理盐水的动物眼部组织学均正常。用角膜缘和佐剂致敏豚鼠导致葡萄膜、小梁和巩膜外层出现单核细胞浸润。以淋巴细胞和浆细胞为主。角膜缘诱导的反应似乎由两个成分组成：一个葡萄膜成分和一个特定的角膜缘成分。葡萄膜的淋巴样浸润与我们葡萄膜对照组中葡萄膜抗原诱导的反应相同。角膜缘成分的特征是小梁和巩膜外层区域有淋巴细胞和浆细胞聚集。本研究表明，角膜缘组织抗原可诱导葡萄膜和角膜缘的炎症反应，且小梁中的炎症反应，角膜缘抗原比葡萄膜抗原更强烈。
