肿瘤促进剂12-O-十四烷酰佛波醇-13-乙酸酯及其非促进类似物4-O-甲基佛波醇-13-乙酸酯对叙利亚金黄地鼠（金仓鼠）背部真皮黑素细胞的影响。
Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and its nonpromoting analogue 4-O-methyl-TPA on dorsal dermal melanocytes of the Syrian golden hamster (Mesocricetus auratus).
作者信息
Goerttler K, Hecker E, Loehrke H, Seip H, Hesse B, Schweitzer J
出版信息
J Cancer Res Clin Oncol. 1982;103(3):305-11. doi: 10.1007/BF00409706.
Abstract
The effect of the tumor promoter TPA and its inactive structural analogue 4-O-methyl-TPA on the induction of dorsal skin melanosis in the normal Syrian golden hamster and on the promotion of melanomas in DMBA-initiated animals was investigated. Both phenomena were observed in TPA-treated hamsters but could not be detected after exposure of animals to 4-O-methyl-TPA. In contrast to results obtained with a variety of other laboratory animals, neither TPA nor 4-O-methyl-TPA were able to induce epidermal hyperplasia of hamster dorsal skin.
摘要
研究了肿瘤启动剂佛波酯（TPA）及其无活性结构类似物4-O-甲基-TPA对正常叙利亚金仓鼠背部皮肤黑素沉着的诱导作用以及对经二甲基苯并蒽（DMBA）启动的动物黑色素瘤的促进作用。在TPA处理的仓鼠中观察到了这两种现象，但在动物暴露于4-O-甲基-TPA后未检测到。与用多种其他实验动物获得的结果相反，TPA和4-O-甲基-TPA均不能诱导仓鼠背部皮肤的表皮增生。
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Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and its nonpromoting analogue 4-O-methyl-TPA on dorsal dermal melanocytes of the Syrian golden hamster (Mesocricetus auratus).肿瘤促进剂12-O-十四烷酰佛波醇-13-乙酸酯及其非促进类似物4-O-甲基佛波醇-13-乙酸酯对叙利亚金黄地鼠（金仓鼠）背部真皮黑素细胞的影响。
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本文引用的文献
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Carcinogen-induced melanotic tumors in the Syrian hamster.致癌物诱导叙利亚仓鼠产生的黑素瘤
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Two-stage tumorigenesis of dermal melanocytes in the back skin of the Syrian golden hamster using systemic initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-O-tetradecanoylphorbol-13-acetate.在叙利亚金仓鼠背部皮肤中，使用7,12-二甲基苯并(a)蒽进行全身启动和12-O-十四酰佛波醇-13-乙酸酯进行局部促癌，诱导真皮黑素细胞发生两阶段肿瘤形成。
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Res Commun Chem Pathol Pharmacol. 1979 Jun;24(3):533-41.
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