Minegishi A, Fukumori R, Satoh T, Kitagawa H
Psychopharmacology (Berl). 1982;77(3):289-91. doi: 10.1007/BF00464582.
Disulfiram prolonged the latency to clonic seizure caused by pentylenetetrazol (PTZ, 100 mg/kg SC). The effect of disulfiram was augmented by combination with tryptophan plus lithium, although neither tryptophan or lithium prolonged the latency to clonic seizure. The latency to tonic seizure was also prolonged in disulfiram-treated animals in parallel with the prolongation of the latency to clonic seizure. Lithium treatment completely prevented the incidence of tonic seizure, while this effect was cancelled in disulfiram-treated animals. Disulfiram acts on the clonic and tonic seizures in different ways.
双硫仑延长了由戊四氮（PTZ，100mg/kg皮下注射）引起的阵挛性发作的潜伏期。双硫仑与色氨酸加锂联合使用时效果增强，尽管色氨酸和锂单独使用时均未延长阵挛性发作的潜伏期。在双硫仑治疗的动物中，强直性发作的潜伏期也随着阵挛性发作潜伏期的延长而延长。锂治疗完全预防了强直性发作的发生，而在双硫仑治疗的动物中这种作用被抵消。双硫仑以不同方式作用于阵挛性发作和强直性发作。
