Pérez-López F R, González-Moreno C M, Abós M D, Andonegui J A, Corvo R H
Acta Endocrinol (Copenh). 1982 Aug;100(4):481-5. doi: 10.1530/acta.0.1000481.
In order to determine whether or not pituitary responsiveness to the dopaminergic antagonist clebopride changes during the nyctohemeral cycle, 10 healthy women with regular cycles were given 1 mg of clebopride orally at 09.00 h and 24.00 h with at least a 5 day interval between each test. In addition, 5 of the women were given a placebo instead of clebopride at midnight to evaluate the spontaneous hormonal changes. During the 24.00 h test the women had significantly higher (P less than 0.05) mean TSH basal levels. Serum prolactin (Prl) increased significantly (P less than 0.001) after clebopride administration while these changes did not occur when placebo was used instead of clebopride at midnight. The Prl response to clebopride was qualitatively similar at 09.00 h and at 24.00 h. Clebopride given at midnight induced a significant increase (P less than 0.05) in serum TSH while this change did not occur when the drug was given at 09.00 h or when placebo was given at midnight. The administration of clebopride resulted in no discernible alternations in serum LH, FSH or GH in either the 09.00 h or the 24.00 h tests. Thus, Prl responses to clebopride were similar in the morning and at midnight, TSH significantly increased after clebopride at midnight whereas this did not occur when the drug was given in the morning, and no significant changes were induced in LH, FSH or GH at the times studied.
为了确定垂体对多巴胺能拮抗剂氯波必利的反应性在昼夜周期中是否会发生变化，对10名月经周期规律的健康女性，分别于上午9点和午夜24点口服1毫克氯波必利，每次测试间隔至少5天。此外，其中5名女性在午夜服用安慰剂而非氯波必利，以评估激素的自然变化。在午夜24点的测试中，女性的促甲状腺激素（TSH）基础平均水平显著更高（P<0.05）。服用氯波必利后血清催乳素（Prl）显著升高（P<0.001），而午夜服用安慰剂而非氯波必利时则未出现这些变化。上午9点和午夜24点时，Prl对氯波必利的反应在性质上相似。午夜服用氯波必利可使血清TSH显著升高（P<0.05），而上午9点服用该药或午夜服用安慰剂时则未出现这种变化。在上午9点或午夜24点的测试中，服用氯波必利后血清促黄体生成素（LH）、促卵泡生成素（FSH）或生长激素（GH）均未出现明显变化。因此，Prl对氯波必利的反应在上午和午夜相似，午夜服用氯波必利后TSH显著升高，而上午服用该药时则未出现这种情况，在所研究的时间点，LH、FSH或GH均未出现显著变化。
