Espié J H, Legendre N, L'Hullier I
C R Seances Acad Sci III. 1982 Jun 14;294(21):995-1000.
Endodontic root filling following pulpectomy in Baboons was shown to induce diphasic consequences at the level of the periodontal ligament according to the time of the observation. Initially the specific activity of previously incorporated 3H Glycine decreased and the weight of extractible ligament increased at the same time. Later on, the turnover slowed down and, unexpectedly, the weight of the extractible ligament decreased. This could be explained since the periodotal ligament was shown to exhibit a transient inflammatory reaction followed initially by a tissue accretion and progressively by a partial amputation of the ligament volume compensated by an excess of bone deposit on the surface of the alveolar bone socket.
根据观察时间，在狒狒牙髓切除术后进行根管充填，结果显示在牙周膜水平会引发双相性后果。最初，先前掺入的3H甘氨酸的比活性降低，同时可提取韧带的重量增加。随后，更新速率减慢，并且出乎意料的是，可提取韧带的重量下降。这是可以解释的，因为已表明牙周膜会出现短暂的炎症反应，最初是组织增生，随后逐渐是韧带体积的部分切除，由牙槽骨窝表面过量的骨沉积来补偿。
