Marks G S, Zelt D T, Cole S P
Can J Physiol Pharmacol. 1982 Jul;60(7):1017-26. doi: 10.1139/y82-146.
Under normal circumstances the heme biosynthetic pathway is carefully controlled and porphyrins are formed in only trace amounts. When control mechanisms are disturbed by xenobiotics, porphyrins may be formed and serve as a signal of the interaction between a xenobiotic and the heme biosynthetic pathway. For example, porphyrinuria was an early manifestation of a hexachlorobenzene-induced porphyria outbreak in Turkey. In humans exposed to polybrominated biphenyls and to 2,3,7,8-tetrachlorodibenzo-p-dioxin the urinary porphyrin pattern was significantly different from normal in a large number of exposed individuals. The question is raised whether measurement of urinary porphyrin profiles by improved methods will enable an estimate to be made of the extent of exposure to haloaromatic hydrocarbons in the human population. A wide variety of xenobiotics interact with the prosthetic heme of cytochrome P-450 forming novel N-alkylporphyrins. Identification of these N-alkylporphyrins in body fluids might provide a means of assessing exposure to a variety of xenobiotics in human populations.
在正常情况下，血红素生物合成途径受到严格调控，卟啉仅以痕量形式形成。当控制机制受到外源性物质干扰时，卟啉可能会形成，并作为外源性物质与血红素生物合成途径之间相互作用的信号。例如，卟啉尿是土耳其六氯苯诱导的卟啉病爆发的早期表现。在接触多溴联苯和2,3,7,8-四氯二苯并对二恶英的人群中，大量接触者的尿卟啉模式与正常情况有显著差异。问题在于，通过改进方法测量尿卟啉谱是否能够估计人群中卤代芳烃的暴露程度。多种外源性物质与细胞色素P-450的辅基血红素相互作用，形成新的N-烷基卟啉。在体液中鉴定这些N-烷基卟啉可能为评估人群中多种外源性物质的暴露情况提供一种方法。
