Zisook S, Rogers P J, Faschingbauer T R, Devaul R A
J Clin Psychiatry. 1978 Aug;39(8):683-5.
A number of benzodiazepine have been shown to increase hostility and aggression. This study examines whether halazepam, a new benzodiazepine structurally very similar to diazepam, is associated with increases in hostility. Fifty-one adult outpatients in a double blind, 6 week study were randomly assigned either halazepam or placebo. Hostility was measured by changes in response on four different scales, the anger-hostility factor of the Patient Symptom Checklist and three MMPI hostility scales. The results of our study indicated that halazepam does not induce significant changes in hositility.
多项研究表明，一些苯二氮卓类药物会增加敌意和攻击性。本研究旨在探讨哈拉西泮（一种在结构上与地西泮非常相似的新型苯二氮卓类药物）是否与敌意增加有关。在一项为期6周的双盲研究中，51名成年门诊患者被随机分配服用哈拉西泮或安慰剂。通过四种不同量表（患者症状清单的愤怒-敌意因子和三种明尼苏达多项人格调查表敌意量表）的反应变化来测量敌意。我们的研究结果表明，哈拉西泮不会引起敌意的显著变化。
